Dale's principle
2 published articles
Sakana AIFeatured1 min read
Biologically Plausible Learning
Sakana AI's MNIST-to-CIFAR flip exposes a blind spot in brain-like AI
Sakana AI scaled a backprop-free, Dale-compliant architecture past MNIST for the first time. The catch: which trick matters most reverses between datasets, a warning about how biologically plausible AI is measured.
2026-07-22
Sakana AI7 min read
Biologically plausible AI's hidden warning
The CIFAR-10 ablation that should make every AI researcher rethink their benchmarks
Sakana AI's Error Diffusion scales brain-like, backprop-free learning to CIFAR-10 and RL. The catch is in the ablation tables: which design choices matter reverses entirely between benchmarks, and the cost of Dale's principle grows with task difficulty.
2026-07-19